ERr713® at 4 mg/day is clinically proven to reduce 8 key symptoms of menopause.1 A systematic review and meta-analysis of 12-week clinical trials highlights multiple benefits and safety of ERr713® to improve the quality of life in menopausal women.

ERr731® balances oestrogen activity. Oestrogen receptors (ER), especially alpha (ER?) and beta (ER?) are widely distributed throughout the body. ER activation initiates many of the important biological actions of oestrogen such as regulating reproductive function, supporting healthy mood, and maintaining skin health. However, excessive ER? activation enables cell proliferation and inflammation, especially in oestrogen-sensitive tissues such as the breast and uterus.5,6 In contrast, activation of ER? promotes anti-inflammatory processes and down regulates ERa receptor expression to balance these effects.7

ERr731® selectively targets ER? to alleviate menopausal symptoms.8 Active constituents, primarily rhaponticin, extracted in ERr731® selectively bind to and activate ER?, without activating ER?.9 This high affinity with ER? is linked to reducing menopausal symptoms without potential side effects.10

Short-and long-term safety and efficacy of ERr731®.2,4 A comprehensive multi-centre trial has demonstrated both short- and long-term benefits of ERr731® supplementation. Initially, a 12-week randomized, double-blind, placebo-controlled trial with 109 women found that 4 mg/day of ERr731® significantly reduced (p<0.0001) the number and severity of hot flushes from 4 weeks. By 12 weeks, overall reductions (p<0.0001) in sleep disturbances, irritability, joint and muscle complaints, low libido, vaginal dryness and fatigue, improved quality of life, with high patient satisfaction. (Figure 1.)

1. Dubey, V. P., Sureja, V. P. & Kheni, D. B. Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731®) on symptoms of menopause: A systematic review and meta-analysis study. J. Biomed. Res. 38, 278–286 (2024).

2. Heger, M. et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints. Menopause 13, 744–759 (2006).

3. Kaszkin-Bettag, M. et al. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Altern Ther Health M 15, 24–34 (2009).

4. Hasper, I. et al. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause 16, 117–131 (2009).

5. Chang, J.-L. et al. Rheum rhaponticum Extract (ERr 731): Postmarketing Data on Safety Surveillance and Consumer Complaints. Integr Medicine Encinitas Calif 15, 34–9 (2016).

6. Gartoulla, P., Worsley, R., Bell, R. J. & Davis, S. R. Moderate to severe vasomotor and sexual symptoms remain problematic for women aged 60 to 65 years. Menopause 25, 1331–1338 (2018).

7. Zheng, J., Islam, R. M., Bell, R. J., Skiba, M. A. & Davis, S. R. Prevalence of Low Sexual Desire With Associated Distress Across the Adult Life Span: An Australian Cross-Sectional Study. J. Sex. Med. 17, 1885–1895 (2020).

8. Wober, J. et al. Activation of estrogen receptor-? by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds. J Steroid Biochem Mol Biology 107, 191–201 (2007).

9. Kaszkin-Bettag, M. et al. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause 14, 270–283 (2007).

Warnings

This product contains Rheum rhaponticum and this product may have laxative effect.

If symptoms persist consult your healthcare professional.

Do not use if cap and/or seals are missing or broken.