Selective Prebiotic:
Partially Hydrolysed Guar Gum (PHGG) is a selective low reactive, FODMAP free prebiotic that is fermented by large intestinal commensal bacteria, increasing short-chain fatty acid (SCFA) production, particularly butyrate.
*Reduction of constipation: PHGG influences gut motility, secretions, and vagal modulation of contraction. It has been demonstrated to reduce methane levels, which are implicated in the reduction of gut serotonin (5HT) levels and decreased intestinal motility.
* Excessive methane production is associated with gastrointestinal issues such as Small intestinal bacterial overgrowth (SIBO), chronic constipation, IBS, and slow transit time. PHGG may help modulate the severity of these conditions and their associated symptoms.
Lactobacillus plantarum 299v, is an extensively researched probiotic shown to reduce a range of IBS symptoms.
Visceral hypersensitivity, abdominal pain and inflammation; Probiotics can help modulate visceral hypersensitivity (increased pain sensitivity) to reduce abdominal pain27 and improve patient comfort. Both L. plantarum 299v and PHGG have been shown to reduce abdominal pain by 50%,28 which can be a key symptom driving patients to seek health advice. Gut inflammation can also contribute to pain and associated symptoms that may benefit from probiotic strains, such as L. plantarum 299v, shown to exert a modulatory effect on the inflammatory response of epithelium,29 helping to improve gastrointestinal comfort and health.